ABSTRACT
Based on ethnophannacological studies, Makahiya (Mimosa pudica L.) root extract is used by the Dumagat tribe to treat malaria. However, no scientific study has been conducted to confirm the anti-malarial property of Makahiya root extractAfter successful inoculation with Plasmodium-infected blood, 30 BalB-C mice consisting of 15 males and 15 females were randomly assigned to receive distilled water, pure root extract, 10.2 diluted root extract, 10.1 diluted root extract and quinine sulfate suspension. Treatments were administered using oral gavage method on an 8-hour interval for 6 consecutive days. Parasitemia was monitored by microscopic examination of Giemsa-stained blood smears taken at the end of each treatment dayBaseline parasitemia levels of the five treatment groups showed no significant difference when subjected to one-way ANOVA. When graphed, all three groups treated with Makahiya root extract appear to be parallel with one another, and showed a slightly increasing trend with slopes of 1.475, 1.4893 and 1.5771 for the treatment groups receiving pure extract, 10-1 ldilution and 10-2 dilution, respectivelyThe negative control group demonstrated a steadily increasing graph, with a slope of 14.25. The group treated with quinine, on the other hand, showed a steadily decreasing graph with a slope of 4.8911One population t-test revealed that a significant difference exists between the slopes of the three makahiya treatment groups. It also revealed a significant difference between the slopes of the three Makahiya groups and distilled water. A significant difference also exists between quinine and the three Makahiya treatment groups using the same testsThe presence of a significant difference between water and the three Makahiya treatment groups shows that Makahiya has an anti-malarial effect. However, the anti-malarial effect is not the same as quinine as shown by a significant difference between the Makahiya and quinine
ABSTRACT
Os autores analisam 27 pacientes operados no Hospital dos Plantadores de Cana com o diagnostico de cancer colorretal, no periodo compreendido entre junho de 1975 e dezembro de 1980. O grupo era composto por 16 pacientes do sexo feminino (59,3%) e 11 do sexo masculino (40,7%).O individuo mais jovem tinha 29 anos e o mais idoso 87, com a media de idade de 55,3 anos. Os tumores estavam distribuidos pelos colons da seguinte maneira: 12 ao nivel do reto (44, 5%), sete localizados no sigmoide (25,9%), tres no colon esquerdo (11,1%) e cinco no colon direito (18,5%). Em dois pacientes havia tumores sincronicos de colon direito e sigmoide. Usando os criterios de Dukes, os tumores foram assim classificados: Tipo A-12, tipo B-8, tipo C-9 e tipo D-8. Histologicamente 25 pacientes eram portadores de adenocarcinomas e dois apresentavam tumores epidermoides. Em 23 pacientes foram realizadas cirurgias de resseccao do tubo digestivo incluindo a massa neoplasica. Em tres doentes as cirurgias visaram unicamente evitar a obstrucao do tubo gastrointestinal. Em um paciente foi praticada excisao local. Desses pacientes tres faleceram no pos-operatorio imediato, perfazendo um indice de mortalidade de 11,1%, 11 vieram a falecer posteriormente a alta hospitalar, com o minimo de sobrevida de 40 dias e o maximo de dois anos. Em 1/6/82 treze pacientes (48,1%) estavam vivos, com sobrevida superior a cinco anos